OpenVaccine: COVID-19 mRNA Vaccine Degradation Prediction

In this competition, we are looking to leverage the data science expertise of the Kaggle community to develop models and design rules for RNA degradation. Your model will predict likely degradation rates at each base of an RNA molecule, trained on a subset of an Eterna dataset comprising over 3000 RNA molecules (which span a panoply of sequences and structures) and their degradation rates at each position. We will then score your models on a second generation of RNA sequences that have just been devised by Eterna players for COVID-19 mRNA vaccines. These final test sequences are currently being synthesized and experimentally characterized at Stanford University in parallel to your modeling efforts – Nature will score your models!


  • October 2, 2020 - Entry deadline. You must accept the competition rules before this date in order to compete.
  • October 2, 2020 - Team Merger deadline. This is the last day participants may join or merge teams.
  • October 5, 2020 - Final submission deadline.


  • 1st Place - $ 12,000
  • 2nd Place - $ 8,000
  • 3rd Place - $ 5,000

Join Competition Here